Real Madrid and Barcelona pulled two points clear in La Liga when Cristiano Ronaldo set a club scoring record in Real's 3-0 stroll against Levante and Neymar hit four as Barca beat Rayo Vallecano 5-2 on Saturday.
A bullet header from Nicolas Otamendi put Valencia on course for a 3-1 victory over Eibar in La Liga on Sunday that boosted their hopes of claiming a Champions League place.
Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Real Madrid kept alive their hopes of overhauling La Liga leaders Barcelona when a James Rodriguez stunner set them on their way to a serene 3-0 home victory over struggling Almeria on Wednesday.
With Real Madrid facing an injury crisis ahead of Wednesday's Champions League clash with Atletico Madrid attention will be on talisman Cristiano Ronaldo to lead them through but James Rodriguez may hold the key.
Barcelona's Lionel Messi hit his 400th career goal for the La Liga leaders.
Barcelona midfielder Andres Iniesta could miss Saturday's La Liga game at home to Valencia after tests on Thursday confirmed he suffered a bruised pelvis in Wednesday's 3-1 Champions League win at Paris St Germain.
Valencia turned up the heat on Atletico Madrid in the fight for third place in La Liga when a 3-0 derby victory at home to Levante on Monday lifted the Singapore-owned club to within a point of the champions with seven games left.
Atletico Madrid made a typically aggressive start to lay the foundations for a 2-0 victory at home.
Gijon spoiled Asier Illarramendi's return to Real Sociedad's midfield after rejoining from Real Madrid this week when they held the Basque club, coached by Scot David Moyes, to a 0-0 draw in San Sebastian.
Treble-chasing Barcelona are exactly where they want to be as they prepare for two matches this week that could make or break coach Luis Enrique's first season in charge.
Antoine Griezmann and Yannick Carrasco each conjured moments of magic as Atletico Madrid recaptured top spot in La Liga from Barcelona with a hard-fought 2-0 victory at Celta Vigo on Sunday.
If Barcelona fail to secure their eighth consecutive UEFA Champions League quarter-final appearance, Lionel Messi's failed penalty at Manchester City on Tuesday could well prove their "what if" moment.
Cristiano Ronaldo's bullet header helped Real Madrid to a 2-0 victory .
Real Madrid closed to within two points of La Liga leaders Barcelona after demolishing nine-man Rayo Vallecano 10-2 while Atletico Madrid missed a chance to seize top spot outright by losing 1-0 at Malaga.
Villarreal set up a King's Cup semis against Barca after Gerard Moreno gave them a 1-0 win
Neymar struck twice as Barca beat Atletico Madrid to reach the King's Cup semis
Espanyol secured a commanding lead in their King's Cup quarter-final tie against Sevilla when Felipe Caicedo, Sergio Garcia, with a penalty, and Lucas Vazquez scored in a 3-1 first-leg home win on Thursday.
Barcelona seized control of their King's Cup quarter-final tie against Atletico Madrid when Lionel Messi followed up his saved penalty to score and secure a 1-0 first-leg victory at the Nou Camp on Wednesday.
Barcelona coach Luis Enrique has decided to rest Lionel Messi, Neymar and most of his regulars for the King's Cup last 16, second leg match at Elche later on Thursday.
We bring you a collection of some of the best photographs taken last week by ace Reuters photogs.
Antoine Griezmann headed two goals for Atletico Madrid in a 3-1 victory over Levante that kept them on the heels of La Liga leaders Real Madrid on Saturday.
Atletico Madrid will face holders Real Madrid in the last 16 of the King's Cup after a double from Mario Mandzukic sealed a 5-2 aggregate victory over lower league Hospitalet on Thursday.
Real Madrid and AC Milan led a procession of six teams into the Champions League last 16 on Wednesday while big-spending Manchester City failed again on the European stage to further dent English soccer's standing.
Atletico Madrid secured a berth in the Champions League group stage for next season and Deportivo La Coruna narrowly escaped relegation when they came from two goals down to draw 2-2 at champions Barcelona on the final day in La Liga on Saturday.
Cristiano Ronaldo grabbed a record 23rd La Liga hat-trick to guide leaders Real Madrid to a 3-0 victory over Celta Vigo. It also helped the European champions extend their club record winning streak to 18 matches in all competitions.
Barcelona have been boosted by the successful return from injury of talismanic playmaker Andres Iniesta as they prepare to host city rivals Espanyol in La Liga on Sunday.
Sevilla joined holders Real Madrid in the last 16 of the King's Cup when a quick-fire Iago Aspas hat-trick helped secure a crushing 11-2 aggregate victory over second-division Sabadell on Wednesday.
Simeone urges Atletico fans to keep violence out of football 'I don't think this (violence) has anything to do with sport and it seems they are using sport to make a greater impact'
Valencia will banish a fan who hit Barcelona forward Lionel Messi on the head with a plastic bottle on Sunday for life once they have been identified, the club said on Monday.
David Moyes notched his maiden victory as coach of Real Sociedad as Carlos Vela scored a classy hat-trick in a morale-boosting 3-0 win at home to Elche in La Liga on Friday.
With the distraction of two individual scoring records safely out of the way, Barcelona forward Lionel Messi can turn his full focus on helping the club win the major silverware that eluded them last season.
Barcelona's Lionel Messi, Luis Suarez and Neymar motored past 100 goals for the season.
Atletico Madrid coach Diego Simeone may have played down the significance of Sunday's 2-1 La Liga defeat at Real Sociedad but it has raised further questions about the champions' ability to defend their title.
Chelsea manager Jose Mourinho said striker Diego Costa will start against Liverpool in the Premier League at Anfield on Saturday despite being left out of the Spain squad for this month's international matches because of persistent injuries.
Manchester United took over at the top of the Premier League while Barcelona's Argentine forward Lionel Messi could be out for up to two months with a knee injury and rampant Bayern Munich extended their perfect start to seven league wins.
Real Madrid's trophy aspirations could well depend on how well they cope with an injury crisis that sees Gareth Bale and Luka Modric in the treatment room.
Sevilla drew level on points with Barcelona at the top of La Liga when they snatched a 2-1 comeback victory at home to Villarreal, while champions Atletico Madrid won 1-0 in a bad-tempered clash at Getafe on Sunday.
Real Madrid's stuttering start to La Liga continued when they lost 1-0 at Sevilla to slip eight points behind leaders Barcelona who were 4-1 victors at Getafe earlier on Saturday.
Manchester United humbled Manchester City 4-2 in the continent's big derby of the weekend.